Lopinavir
Chemical compound / From Wikipedia, the free encyclopedia
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Lopinavir is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir).[1]
Quick Facts Clinical data, Other names ...
Clinical data | |
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Other names | ABT-378 |
AHFS/Drugs.com | International Drug Names |
MedlinePlus | a602015 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | Unknown |
Protein binding | 98-99% |
Metabolism | Liver |
Elimination half-life | 5 to 6 hours |
Excretion | Mostly fecal |
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ECHA InfoCard | 100.281.362 |
Chemical and physical data | |
Formula | C37H48N4O5 |
Molar mass | 628.814 g·mol−1 |
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It was patented in 1995 and approved for medical use in 2000.[2] Considered now as second-line therapy in the West, it is still prescribed in LMIC, especially among children living with HIV. Lopinavir and ritonavir can be taken as a tablet or an oral solution, a preferred option in children. In the early stages of COVID-19 pandemics, lopinavir was repurposed against the SARS-CoV-2 virus in the hope of disturbing its protease activity.[3]