Lopinavir/ritonavir
Combination medication for HIV/AIDS / From Wikipedia, the free encyclopedia
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Lopinavir/ritonavir (LPV/r), sold under the brand name Kaletra among others, is a fixed-dose combination antiretroviral medication for the treatment and prevention of HIV/AIDS.[2] It combines lopinavir with a low dose of ritonavir.[2] It is generally recommended for use with other antiretrovirals.[2] It may be used for prevention after a needlestick injury or other potential exposure.[2] It is taken by mouth as a tablet, capsule, or solution.[2]
Combination of | |
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Lopinavir | Protease inhibitor |
Ritonavir | Protease inhibitor (pharmacokinetic booster) |
Clinical data | |
Trade names | Kaletra, Aluvia |
AHFS/Drugs.com | Monograph |
MedlinePlus | a602015 |
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Routes of administration | By mouth |
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Common side effects include diarrhea, vomiting, feeling tired, headaches, and muscle pains.[2] Severe side effects may include pancreatitis, liver problems, and high blood sugar.[2] It is commonly used in pregnancy and it appears to be safe.[2] Both medications are HIV protease inhibitors.[2] Ritonavir functions by slowing down the breakdown of lopinavir.[2]
Lopinavir/ritonavir as a single medication was approved for use in the United States in 2000.[2] It is on the World Health Organization's List of Essential Medicines.[3]