User:Mr. Ibrahem/Multisystem inflammatory syndrome in children
Medical condition / From Wikipedia, the free encyclopedia
Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory multisystem syndrome (PIMS), is a disease in children associated with COVID-19.[5] Symptoms may include ongoing fever plus abdominal pain, diarrhea, red eyes, rash, or vomiting.[5][6] Complications may include heart, lung, kidney, skin, or brain problems.[6]
Multisystem inflammatory syndrome in children (MIS-C) | |
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Other names | |
Electron microscope image of SARS-CoV-2, the virus responsible for COVID-19 | |
Specialty | Pediatrics |
Symptoms | Fever, abdominal pain, diarrhea, red eyes, rash, vomiting[5][6] |
Complications | Heart, lung, kidney, skin, or brain problems[6] |
Usual onset | 2–6 weeks after COVID-19[7] |
Causes | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[5] |
Diagnostic method | Based on symptoms and blood tests after ruling out other causes[8] |
Differential diagnosis | Kawasaki disease[9] |
Prevention | Protecting children from COVID-19[6] |
Management | Supportive care[8] |
Medication | IVIG, steroids, aspirin[8][10] |
Prognosis | Long-term outcomes unclear[10] |
Frequency | 1 in 3,000 after COVID-19[10] |
Deaths | 1 to 2%[9] |
It generally occurs around 2 to 6 weeks after COVID-19.[9][7] While it occurs more often in the obese, those affected are generally otherwise healthy.[9] Diagnosis is based on symptoms with laboratory signs of inflammation and multiple body system involvement, after ruling out other possible causes.[8] Serologic testing for prior SARS-CoV-2 may be useful.[8] Other conditions that may appear similar include Kawasaki disease.[9]
Prevention is by protecting children from COVID-19.[6] Treatment is primarily supportive care; which may include intravenous fluids, inotropes, and support of breathing.[8] In severe cases extracorporeal membranous oxygenation (ECMO) may be required.[8] IVIG, steroids, and aspirin are often used.[8][10] About 80% of those affected require intensive care.[9]
MIS-C affects about 1 in 3,000 children infected by COVID-19.[10] Those around the age of 9 are most commonly affected.[10] In the United States it more common in Black and Hispanic children.[10] Death occurred in about 1 to 2% of cases.[9] The condition was first described in April of 2020.[10] Adults may develop a similar condition known as multisystem inflammatory syndrome in adults (MIS-A).[9]