Trandolapril
Antihypertensive drug of the ACE inhibitor class / From Wikipedia, the free encyclopedia
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"Mavik" redirects here. Not to be confused with Mavic.
Trandolapril is an ACE inhibitor used to treat high blood pressure. It may also be used to treat other conditions. It is similar in structure to another ramipril but has a cyclohexane group. It is a prodrug that must be metabolized into its active form. It has a longer half-life when compared to other agents in this class.
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Mavik, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697010 |
Routes of administration | By mouth |
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Pharmacokinetic data | |
Protein binding | Trandolapril 80% (independent of concentration) Trandolaprilat 65 to 94% (concentration-dependent) |
Metabolism | Liver |
Elimination half-life | 6 hours (trandolapril) 10 hours (trandolaprilat) |
Excretion | Fecal and Kidney |
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ECHA InfoCard | 100.108.532 |
Chemical and physical data | |
Formula | C24H34N2O5 |
Molar mass | 430.545 g·mol−1 |
3D model (JSmol) | |
Melting point | 119 to 123 °C (246 to 253 °F) |
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It was patented in 1981 and approved for medical use in 1993.[1] It is marketed by Abbott Laboratories under the brand name Mavik.