Ramipril
ACE inhibitor medication / From Wikipedia, the free encyclopedia
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Ramipril, sold under the brand name Altace among others, is an ACE inhibitor type medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[1] It can also be used as a preventative medication in patients over 55 years old to reduce the risk of having a heart attack, stroke or cardiovascular death in patients shown to be at high risk, such as some diabetics and patients with vascular disease.[2][3][4] It is a reasonable initial treatment for high blood pressure.[1] It is taken by mouth.[1]
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Trade names | Altace, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692027 |
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Routes of administration | By mouth |
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Bioavailability | 28% |
Protein binding | 73% (ramipril) 56% (ramiprilat) |
Metabolism | Liver, to ramiprilat |
Elimination half-life | 13 to 17 hours |
Excretion | Kidney (60%) and fecal (40%) |
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ECHA InfoCard | 100.170.726 |
Chemical and physical data | |
Formula | C23H32N2O5 |
Molar mass | 416.518 g·mol−1 |
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Melting point | 109 °C (228 °F) |
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Common side effects include headaches, dizziness, fatigue, and cough.[1] Serious side effects may include liver problems, angioedema, kidney problems, and high blood potassium.[1] Use in pregnancy and breastfeeding is not recommended.[5] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[1]
Ramipril was patented in 1981 and approved for medical use in 1989.[6] It is available as a generic medication.[7] In 2021, it was the 201st most commonly prescribed medication in the United States, with more than 2 million prescriptions.[8][9]