Simnotrelvir/ritonavir
Antiviral combination medication / From Wikipedia, the free encyclopedia
Simnotrelvir/ritonavir (trade name Xiannuoxin) is a pharmaceutical drug used for the treatment of COVID-19.[2] Simnotrelvir/ritonavir is a combination drug of simnotrelvir, an inhibitor of SARS-CoV-2 3CLpro, and ritonavir,[3] a CYP3A inhibitor.
Quick Facts Combination of, Ritonavir ...
Combination of | |
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Simnotrelvir | SARS-CoV-2 3CLpro inhibitor |
Ritonavir | Protease inhibitor |
Clinical data | |
Trade names | 先诺欣 (Xiannuoxin) |
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Routes of administration | Oral |
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Quick Facts Clinical data, Other names ...
Clinical data | |
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Other names | SIM0417, SSD8432 |
Routes of administration | Oral |
Drug class | SARS-CoV-2 3CLpro inhibitor |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | 72.5%[1] |
Metabolism | hepatic (CYP3A)[1] |
Elimination half-life | 3.1 h; 4.1 h with ritonavir[1] |
Excretion | urine (55.4%), feces (36.7%)[1] |
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Chemical and physical data | |
Formula | C22H30F3N5O4S2 |
Molar mass | 549.63 g·mol−1 |
3D model (JSmol) | |
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It was developed by Simcere Pharmaceutical and conditionally approved in China by the National Medical Products Administration (NMPA) in January 2023.[4] Results for the phase Ib trial are available.[5] In a phase II/III trial, it reduced the duration of symptoms by a median of 36 hours compared to placebo.[6]