Indapamide
Thiazide-like diuretic drug / From Wikipedia, the free encyclopedia
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Indapamide is a thiazide-like diuretic[2] drug used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are available. The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in hypertensive patients compared with hydrochlorothiazide with a comparable incidence of adverse events.[3] Both thiazide diuretics and thiazide-like diuretics are effective in reducing risk of stroke.[3][4][5] Both drug classes appear to have comparable rates of adverse effects as other antihypertensives such as angiotensin II receptor blockers and dihydropyridine calcium channel blockers and lesser prevalence of side-effects when compared to ACE-inhibitors and non-dihydropyridine calcium channel blockers.[3][6]
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Trade names | Lozol, Natrilix |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684062 |
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Routes of administration | By mouth |
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Protein binding | 71–79% |
Metabolism | Liver |
Elimination half-life | 14–18 hours |
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ECHA InfoCard | 100.043.633 |
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Formula | C16H16ClN3O3S |
Molar mass | 365.83 g·mol−1 |
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It was patented in 1968 and approved for medical use in 1977.[7] It is on the World Health Organization's List of Essential Medicines.[8]