Perindopril
High blood pressure medication / From Wikipedia, the free encyclopedia
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Perindopril is a medication used to treat high blood pressure, heart failure, or stable coronary artery disease.[2]
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Trade names | Coversyl, Coversum, Aceon |
AHFS/Drugs.com | Monograph |
Routes of administration | By mouth |
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Bioavailability | 24% |
Protein binding | 20% |
Metabolism | Kidney |
Elimination half-life | 1–17 hours for perindoprilat (active metabolite) |
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ECHA InfoCard | 100.120.843 |
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Formula | C19H32N2O5 |
Molar mass | 368.474 g·mol−1 |
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As a long-acting ACE inhibitor, it works by relaxing blood vessels and decreasing blood volume. As a prodrug, perindopril is hydrolyzed in the liver to its active metabolite, perindoprilat. It was patented in 1980 and approved for medical use in 1988.[3]
Perindopril is taken in the form of perindopril arginine (with arginine, trade names include Coversyl, Coversum) or perindopril erbumine (with erbumine (tert-Butylamine), trade name Aceon). Both forms are therapeutically equivalent and interchangeable,[4] but the dose prescribed to achieve the same effect differs between the two forms. It is also often combined with another medication, sometimes in the same tablet (see § Combination therapy below).