Darunavir
Antiretroviral medication / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Darunavir?
Summarize this article for a 10 year old
Darunavir (DRV), sold under the brand name Prezista among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.[1] It is generally recommended for use with other antiretrovirals.[1][4] It is often used with low doses of ritonavir or cobicistat to increase darunavir levels.[1] It may be used for prevention after a needlestick injury or other potential exposure.[1] It is taken by mouth once to twice a day.[1]
Clinical data | |
---|---|
Trade names | Prezista, others[1] |
Other names | TMC114, DRV, darunavir ethanolate |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607042 |
License data | |
Pregnancy category |
|
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 37% (without ritonavir), 82% (with ritonavir) |
Protein binding | 95% |
Metabolism | Liver (CYP3A4) |
Elimination half-life | 15 hours (with ritonavir) |
Excretion | Feces (80%), urine (14%) |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
NIAID ChemDB | |
PDB ligand | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.111.730 |
Chemical and physical data | |
Formula | C27H37N3O7S |
Molar mass | 547.67 g·mol−1 |
3D model (JSmol) | |
| |
| |
NY (what is this?) (verify) |
Common side effects include diarrhea, nausea, abdominal pain, headache, rash and vomiting.[1][4] Severe side effects include allergic reactions, liver problems, and skin rashes such as toxic epidermal necrolysis.[1] While poorly studied in pregnancy it appears to be safe for the baby.[2] It is of the protease inhibitor (PI) class and works by blocking HIV protease.[1]
Developed by pharmaceutical company Tibotec, darunavir is named after Arun K. Ghosh, the chemistry professor who discovered the molecule at the University of Illinois at Chicago.[5] It was approved by the Food and Drug Administration (FDA) in June 2006.[6] It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication.[8]
The fixed-dose combination medication darunavir/cobicistat (Prezcobix, Rezolsta) is available as a single pill.[9]