Ku70 jest protein koji je kod ljudi kodiran genom XRCC6sa hromosoma 22.[5][6]
Kratke činjenice Dostupne strukture, PDB ...
Ku70 |
---|
|
|
Identifikatori |
---|
Aliasi | XRCC6 |
---|
Vanjski ID-jevi | OMIM: 152690 MGI: 95606 HomoloGene: 37483 GeneCards: XRCC6 |
---|
|
|
Ontologija gena |
---|
Molekularna funkcija | • nucleotide binding • double-stranded telomeric DNA binding • telomeric DNA binding • GO:0008026 helicase activity • 5'-deoxyribose-5-phosphate lyase activity • GO:0004003 DNA helicase activity • protein C-terminus binding • catalytic activity • GO:0001948, GO:0016582 vezivanje za proteine • lyase activity • hydrolase activity • ATP binding • vezivanje sa DNK • double-stranded DNA binding • oštećeno vezivanje sa DNK • vezivanje sa RNK • cyclin binding • GO:0032403 protein-containing complex binding
|
---|
Ćelijska komponenta | • citosol • nuclear telomere cap complex • membrana • transcription regulator complex • hromosom • nukleoplazma • nonhomologous end joining complex • jedro • Ku70:Ku80 complex • citoplazma • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen • protein-DNA complex • Jedarce • GO:0009327 makromolekulani kompleks
|
---|
Biološki proces | • double-strand break repair via classical nonhomologous end joining • protein heterotetramerization • GO:0009373 regulation of transcription, DNA-templated • regulation of smooth muscle cell proliferation • transcription, DNA-templated • cellular response to DNA damage stimulus • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • DNA ligation • establishment of integrated proviral latency • metabolizam • GO:0045996 negative regulation of transcription, DNA-templated • double-strand break repair via nonhomologous end joining • telomere maintenance • positive regulation of type I interferon production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • DNA duplex unwinding • GO:0100026 Popravka DNK • cellular hyperosmotic salinity response • brain development • DNA recombination • neutrophil degranulation • cellular response to gamma radiation • cellular response to X-ray • positive regulation of protein kinase activity • activation of innate immune response • immune system process • Urođeni imunski sistem
|
---|
Izvori:Amigo / QuickGO |
|
Ortolozi |
---|
Vrste | Čovjek | Miš |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNK) | | |
---|
RefSeq (bjelančevina) | | |
---|
Lokacija (UCSC) | Chr 22: 41.62 – 41.66 Mb | Chr 15: 81.87 – 81.92 Mb |
---|
PubMed pretraga | [3] | [4] |
---|
Wikipodaci |
|
Zatvori