Histon-acetiltransferaza p300, znana i kao p300 HAT ili E1A-vezani protein p300 (gdje je E1A = adenovirusna rana regija 1A) također poznat kao i kao EP300 ili p300, jest enzim koji je kod ljudi kodiran genom EP300 sa hromosoma 22.[5] Funkcioniše kao histon-acetiltransferaza koja reguliše transkripciju gena putem remodeliranja hromatina, dozvoljavajući histonskim proteinima da manje čvrsto omotaju DNK. Ovaj enzim ima esencijalnu ulogu u regulaciji ćelijskog rasta i diobe, podstičući ćelije da sazrijevaju i preuzmu specijalizirane funkcije (diferencijacije), te sprječavaju rast kancerogenih tumora. Čini se da je protein p300 kritičan za normalan razvoj prije i nakon rođenja.
Kratke činjenice Dostupne strukture, PDB ...
EP300 |
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Dostupne strukture |
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PDB | Pretraga ortologa: PDBe RCSB |
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Spisak PDB ID kodova |
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1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3 |
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Identifikatori |
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Aliasi | EP300 |
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Vanjski ID-jevi | OMIM: 602700 MGI: 1276116 HomoloGene: 1094 GeneCards: EP300 |
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Ontologija gena |
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Molekularna funkcija | • protein C-terminus binding • transcription factor binding • GO:0001104 transcription coregulator activity • vezivanje iona metala • acyltransferase activity • aktivnost sa transferazom • beta-catenin binding • pre-mRNA intronic binding • vezivanje iona cinka • chromatin binding • oštećeno vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • acetyltransferase activity • vezivanje sa DNK • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • p53 binding • androgen receptor binding • chromatin DNA binding • histone acetyltransferase activity • lysine N-acetyltransferase activity, acting on acetyl phosphate as donor • peptide N-acetyltransferase activity • peptide-lysine-N-acetyltransferase activity • protein propionyltransferase activity • STAT family protein binding • peptide butyryltransferase activity • histone crotonyltransferase activity • histone butyryltransferase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Ćelijska komponenta | • jedro • histone acetyltransferase complex • transcription regulator complex • nukleoplazma • citoplazma • citosol • hromosom
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Biološki proces | • somitogenesis • rhythmic process • transcription by RNA polymerase II • histone H2B acetylation • animal organ morphogenesis • ćelijski ciklus • B cell differentiation • GO:0097285 apoptoza • GO:0009373 regulation of transcription, DNA-templated • lung development • N-terminal peptidyl-lysine acetylation • platelet formation • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • regulation of transcription from RNA polymerase II promoter in response to hypoxia • GO:0022415 viral process • protein acetylation • Notch signaling pathway • cellular response to UV • protein stabilization • positive regulation of DNA-binding transcription factor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • nervous system development • regulation of autophagy • regulation of androgen receptor signaling pathway • positive regulation of protein binding • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • fat cell differentiation • positive regulation by host of viral transcription • megakaryocyte development • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • internal protein amino acid acetylation • regulation of cell cycle • regulation of tubulin deacetylation • GO:1901313 positive regulation of gene expression • histone H4 acetylation • regulation of cellular response to heat • transcription-coupled nucleotide-excision repair • skeletal muscle tissue development • positive regulation of type I interferon production • response to estrogen • response to hypoxia • regulation of signal transduction by p53 class mediator • internal peptidyl-lysine acetylation • beta-catenin-TCF complex assembly • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • macrophage derived foam cell differentiation • Jednodnevni biološki ritam • protein deubiquitination • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • protein destabilization • regulation of megakaryocyte differentiation • histone acetylation • epigenetic maintenance of chromatin in transcription-competent conformation • peptidyl-lysine propionylation • peptidyl-lysine crotonylation • peptidyl-lysine butyrylation
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 22: 41.09 – 41.18 Mb | Chr 15: 81.47 – 81.54 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Gen EP300 se nalazi na dugom (q) kraku ljudskog hromosoma 22 na poziciji 13.2. Ovaj gen kodira adenovirusni E1A povezan sa ćelijskim p300 transkripcijskim koaktivatorskim proteinom.
EP300 je blisko povezan sa drugim genom, CREB vezujući protein, koji se nalazi na ljudskom hromosomu 16.