Protein regije klasterske prelomne tačke'" (BCR), znan I kao antigen bubrežnog karcinoma NY-REN-26 jest protein koji je kod ljudi kodiran genom BCR sa hromosoma 22.
BCR je jedan od dva gena u kompleksu BCR-ABL, koji je povezan sa filadelfija hromosomom. Za ovaj gen su pronađene dvije varijante transkripta koje kodiraju različite izoforme.
Kratke činjenice Dostupne strukture, PDB ...
BCR |
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Identifikatori |
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Aliasi | BCR |
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Vanjski ID-jevi | OMIM: 151410 MGI: 88141 HomoloGene: 3192 GeneCards: BCR |
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Ontologija gena |
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Molekularna funkcija | • aktivnost sa transferazom • nucleotide binding • guanyl-nucleotide exchange factor activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje enzima • protein tyrosine kinase activity • ATP binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity
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Ćelijska komponenta | • citoplazma • citosol • postsynaptic membrane • membrana • GO:0097483, GO:0097481 postsynaptic density • ćelijska membrana • sinapsa • međućelijske veze • Egzosom • GO:0009327 makromolekulani kompleks • Schaffer collateral - CA1 synapse • glutamatergic synapse • postsynaptic density, intracellular component • intracellular anatomical structure
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Biološki proces | • positive regulation of phagocytosis • GO:0007243 intracellular signal transduction • neuromuscular process controlling balance • Fosforilacija • regulation of cell cycle • negative regulation of blood vessel remodeling • protein phosphorylation • negative regulation of cellular extravasation • response to lipopolysaccharide • brain development • regulation of vascular permeability • negative regulation of cell migration • negative regulation of neutrophil degranulation • inner ear morphogenesis • protein autophosphorylation • platelet-derived growth factor receptor signaling pathway • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • negative regulation of inflammatory response • actin cytoskeleton organization • GO:0072468 Transdukcija signala • peptidyl-tyrosine phosphorylation • renal system process • homeostasis of number of cells • regulation of nitrogen compound metabolic process • definitive hemopoiesis • negative regulation of respiratory burst • intracellular protein transmembrane transport • cellular response to lipopolysaccharide • negative regulation of reactive oxygen species metabolic process • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • modulation of chemical synaptic transmission • small GTPase mediated signal transduction • keratinocyte differentiation • focal adhesion assembly • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 22: 23.18 – 23.32 Mb | Chr 10: 74.9 – 75.02 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Kratke činjenice Oligomerizacijski domen onkoproteina Bcr-Abl, Identifikatori ...
Oligomerizacijski domen onkoproteina Bcr-Abl |
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Oligomerizacijski domen strukture onkoproteina bcr-abl |
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Simbol | Bcr-Abl_Oligo |
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Zatvori