Voclosporin
Chemical compound / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Voclosporin?
Summarize this article for a 10 year old
SHOW ALL QUESTIONS
Voclosporin, sold under the brand name Lupkynis, is a calcineurin inhibitor used as an immunosuppressant medication for the treatment of lupus nephritis.[1][4] It is an analog of ciclosporin that has enhanced action against calcineurin and greater metabolic stability.[5]
Quick Facts Names, Identifiers ...
Names | |
---|---|
Systematic IUPAC name
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhepta-4,6-dien-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone | |
Other names
VCS, ISA247, Luveniq | |
Identifiers | |
3D model (JSmol) |
|
ChemSpider | |
ECHA InfoCard | 100.357.472 |
PubChem CID |
|
UNII | |
| |
| |
Properties | |
C63H111N11O12 | |
Molar mass | 1214.646 g·mol−1 |
Pharmacology | |
L04AD03 (WHO) | |
By mouth | |
Legal status | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Close
Quick Facts Clinical data, Trade names ...
Clinical data | |
---|---|
Trade names | Lupkynis |
License data |
|
Legal status | |
Legal status | |
Identifiers | |
DrugBank | |
KEGG | |
ECHA InfoCard | 100.357.472 |
Close
It was approved for medical use in the United States in January 2021,[6][7][8] and in the European Union in September 2022.[2] The U.S. Food and Drug Administration considers it to be a first-in-class medication.[9]