Vitamin K reaction
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Vitamin K reactions are adverse side effects that may occur after injection with vitamin K.[1] The liver utilizes vitamin K to produce coagulation factors that help the body form blood clots which prevent excessive bleeding.[2][3] Vitamin K injections are administered to newborns as a preventative measure to reduce the risk of hemorrhagic disease of the newborn (HDN).[4][5]
The coagulation pathway helps the body stop active bleeds by using vitamin K dependent clotting factors (factors II, VII, IX, and X) which are synthesized by the liver.[2][3][6] Vitamin K can be delivered into the body via the oral, subcutaneous, intramuscular, or intravenous routes of administration.[7]
Vitamin K can influence bone health, coagulation, and insulin sensitivity, but it can also be effected by bariatric surgery which can result in vitamin K deficiency.[8][9][10][11] Vitamin K reactions, such as dermatological and anaphylactic reactions, can cause itchiness, reddening of superficial skin, difficulty breathing, and changes to blood pressure.[12][6][13]