Vinorelbine
Pharmaceutical drug / From Wikipedia, the free encyclopedia
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Vinorelbine (NVB), sold under the brand name Navelbine among others, is a chemotherapy medication used to treat a number of types of cancer.[4] This includes breast cancer and non-small cell lung cancer.[4] It is given by injection into a vein or by mouth.[4][1]
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Trade names | Navelbine |
AHFS/Drugs.com | Monograph |
MedlinePlus | a695013 |
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Routes of administration | intravenous, by mouth[1] |
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Bioavailability | 43 ± 14% (oral)[3] |
Protein binding | 79 to 91% |
Metabolism | liver (CYP3A4-mediated) |
Elimination half-life | 27.7 to 43.6 hours |
Excretion | Fecal (46%) and kidney (18%) |
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Formula | C45H54N4O8 |
Molar mass | 778.947 g·mol−1 |
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Common side effects include bone marrow suppression, pain at the site of injection, vomiting, feeling tired, numbness, and diarrhea.[4] Other serious side effects include shortness of breath.[4] Use during pregnancy may harm the baby.[4] Vinorelbine is in the vinca alkaloid family of medications.[1] It is believed to work by disrupting the normal function of microtubules and thereby stopping cell division.[4]
Vinorelbine was approved for medical use in the United States in 1994.[4] It is on the World Health Organization's List of Essential Medicines.[5][6]