Solifenacin
Chemical compound / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Solifenacin?
Summarize this article for a 10 year old
Solifenacin, sold as the brand name Vesicare[lower-alpha 1] among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO).[1][2] It may help with incontinence, urinary frequency, and urinary urgency.[3]
Clinical data | |
---|---|
Trade names | Vesicare, Vesicare LS |
Other names | YM905 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a605019 |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 90% |
Protein binding | 98% |
Metabolism | CYP3A4 |
Metabolites | Glucuronide, N-oxide, others |
Elimination half-life | 45 to 68 hours |
Excretion | Kidney (69.2%) and fecal (22.5%) |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank |
|
ChemSpider |
|
UNII | |
KEGG |
|
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C23H26N2O2 |
Molar mass | 362.473 g·mol−1 |
3D model (JSmol) | |
| |
| |
NY (what is this?) (verify) |
Benefits appear similar to other medications in the class.[4] It is taken by mouth.[1]
Common side effects include dry mouth, constipation, and urinary tract infection.[1][2] Severe side effects may include urinary retention, QT prolongation, hallucinations, glaucoma, and anaphylaxis.[1][3][2] It is unclear if use is safe during pregnancy.[1] It is of the antimuscarinic class and works by decreasing bladder contractions.[1]
Solifenacin was approved for medical use in the United States in 2004.[1][2][5] In 2021, it was the 228th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[6][7]