Sclerostin
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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"SOST" redirects here. For other uses, see Sost (disambiguation).
Sclerostin is a protein that in humans is encoded by the SOST gene.[5] It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced primarily by the osteocyte but is also expressed in other tissues,[6] and has anti-anabolic effects on bone formation.[7]
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