Prochlorperazine
Medication for nausea, psychosis, and anxiety / From Wikipedia, the free encyclopedia
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Prochlorperazine, formerly[5] sold under the brand name Compazine among others, is a medication used to treat nausea, migraines, schizophrenia, psychosis and anxiety.[6][7][8][9] It is a less preferred medication for anxiety.[6] It may be taken by mouth, rectally, injection into a vein, or injection into a muscle.[6]
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Trade names | Compazine, Stemetil, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682116 |
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Routes of administration | Oral administration, rectal administration, intramuscular injection, intravenous injection (IV) |
Drug class | Typical antipsychotic |
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Bioavailability | Unknown, but presumed substantial |
Protein binding | 91–99% |
Metabolism | Mainly Liver (CYP2D6 and/or CYP3A4) |
Elimination half-life | 4–8 hours, differs with the method of administration |
Excretion | Bile duct, (colored) inactive metabolites in urine |
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ECHA InfoCard | 100.000.345 |
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Formula | C20H24ClN3S |
Molar mass | 373.94 g·mol−1 |
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Common side effects include sleepiness, blurry vision, low blood pressure, and dizziness.[6] Serious side effects may include movement disorders including tardive dyskinesia and neuroleptic malignant syndrome.[6] Use in pregnancy and breastfeeding is generally not recommended.[10] It is a typical antipsychotic which is believed to work by reducing the action of dopamine in the brain.[6]
Prochlorperazine was approved for medical use in the United States in 1956.[6] It is available as a generic medication.[7] In 2020, it was the 355th most commonly prescribed medication in the United States, with more than 600 thousand prescriptions.[11][12]