Pirfenidone
Chemical compound / From Wikipedia, the free encyclopedia
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Pirfenidone, sold under the brand name Pirespa among others, is a medication used for the treatment of idiopathic pulmonary fibrosis. It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
Quick Facts Clinical data, Trade names ...
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Trade names | Esbriet, Pirespa, Etuary |
AHFS/Drugs.com | Monograph |
MedlinePlus | a615008 |
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Routes of administration | By mouth |
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Protein binding | 50–58%[7] |
Metabolism | Liver (70–80% CYP1A2-mediated; minor contributions from CYP2C9, CYP2C19, CYP2D6 and CYP2E1)[7] |
Elimination half-life | 2.4 hours[7] |
Excretion | Urine (80%)[7] |
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ECHA InfoCard | 100.150.129 |
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Formula | C12H11NO |
Molar mass | 185.226 g·mol−1 |
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Solubility in water | 10mg/mL at 60 °C |
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It was first approved in Japan for the treatment of people with idiopathic pulmonary fibrosis after clinical trials in 2008. It was approved for use in the European Union in 2011,[8][6] in Canada in 2012,[4] and in the United States in October 2014.[5][9]
It is available as a generic medication.[10]