Phillip Allen Sharp
American geneticist and molecular biologist / From Wikipedia, the free encyclopedia
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Phillip Allen Sharp (born June 6, 1944) is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence".[2][3][4][5][6][7] He has been selected to receive the 2015 Othmer Gold Medal.[8]
Phillip Allen Sharp | |
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Born | (1944-06-06) June 6, 1944 (age 79) Falmouth, Kentucky, U.S. |
Alma mater | |
Spouse |
Ann Holcombe (m. 1964) |
Children | 3 |
Awards |
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Scientific career | |
Fields | Biologist |
Institutions | |
Doctoral students | |
Website | web |
External videos | |
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Meet Phillip Sharp: "What we were able to discover was that in human cells and in many other cells of higher-order organisms, the genes come in discontinuous segments", MIT |
Sharp's current research focuses on small RNAs and other types of non-coding RNAs. His laboratory works to identify the target mRNAs of microRNAs (miRNAs), and has discovered a class of miRNAs that are produced from sequences adjacent to transcription start sites. His laboratory also studies how miRNA gene regulation functions in angiogenesis and cellular stress.[9][10][11][12]