Nabilone
Synthetic cannabinoid / From Wikipedia, the free encyclopedia
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Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain.[1][2] It mimics tetrahydrocannabinol (THC), the primary psychoactive compound found naturally occurring in Cannabis.[3]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Cesamet, Canemes |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607048 |
Routes of administration | By mouth (capsules) |
Drug class | Cannabinoid |
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Pharmacokinetic data | |
Bioavailability | 20% after first-pass by the liver |
Protein binding | similar to THC (±97%) |
Elimination half-life | 2 hours, with metabolites around 35 hours |
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ECHA InfoCard | 100.164.824 |
Chemical and physical data | |
Formula | C24H36O3 |
Molar mass | 372.549 g·mol−1 |
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The Food and Drug Administration in the United States has indicated nabilone for chemotherapy-induced nausea/vomiting. In other countries, such as Canada, it is widely used as an adjunct therapy for chronic pain management. Numerous trials and case studies have demonstrated modest effectiveness for relieving fibromyalgia[4] and multiple sclerosis.[5][6]