Myelin-associated glycoprotein
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Myelin-associated glycoprotein (MAG, Siglec-4) is a type 1 transmembrane protein glycoprotein localized in periaxonal Schwann cell and oligodendrocyte membranes, where it plays a role in glial-axonal interactions. MAG is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR.[5] MAG is believed to be involved in myelination during nerve regeneration in the PNS[6] and is vital for the long-term survival of the myelinated axons following myelinogenesis.[7] In the CNS MAG is one of three main myelin-associated inhibitors of axonal regeneration after injury,[8] making it an important protein for future research on neurogenesis in the CNS.