Lossen rearrangement
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Quick Facts Identifiers ...
Lossen rearrangement | |
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Named after | Wilhelm Lossen |
Reaction type | Rearrangement reaction |
Identifiers | |
RSC ontology ID | RXNO:0000156 |
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The Lossen rearrangement is the conversion of a hydroxamate ester to an isocyanate. Typically O-acyl, sulfonyl, or phosphoryl O-derivative are employed.[1][2][3][4] The isocyanate can be used further to generate ureas in the presence of amines or generate amines in the presence of H2O.