Langhans giant cell
Cell type / From Wikipedia, the free encyclopedia
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Not to be confused with Langerhans cell.
Langhans giant cells (LGC) are giant cells found in granulomatous conditions.
They are formed by the fusion of epithelioid cells (macrophages), and contain nuclei arranged in a horseshoe-shaped pattern in the cell periphery.[1]
Although traditionally their presence was associated with tuberculosis, they are not specific for tuberculosis or even for mycobacterial disease. In fact, they are found in nearly every form of granulomatous disease, regardless of etiology.