Hofmann rearrangement
Type of chemical reaction / From Wikipedia, the free encyclopedia
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The Hofmann rearrangement (Hofmann degradation) is the organic reaction of a primary amide to a primary amine with one less carbon atom.[1][2][3] The reaction involves oxidation of the nitrogen followed by rearrangement of the carbonyl and nitrogen to give an isocyanate intermediate. The reaction can form a wide range of products, including alkyl and aryl amines.
Quick Facts Identifiers ...
Hofmann rearrangement | |
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Named after | August Wilhelm von Hofmann |
Reaction type | Rearrangement reaction |
Identifiers | |
RSC ontology ID | RXNO:0000410 |
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The reaction is named after its discoverer, August Wilhelm von Hofmann, and should not be confused with the Hofmann elimination, another name reaction for which he is eponymous.