Histone H4
One of the five main histone proteins involved in the structure of chromatin / From Wikipedia, the free encyclopedia
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Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the 'beads on a string' organization. Histone proteins are highly post-translationally modified. Covalently bonded modifications include acetylation and methylation of the N-terminal tails. These modifications may alter expression of genes located on DNA associated with its parent histone octamer.[1][2] Histone H4 is an important protein in the structure and function of chromatin, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.
H4 histone, family 3 | |||||||
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Identifiers | |||||||
Symbol | H4F3 | ||||||
NCBI gene | 3023 | ||||||
HGNC | 4780 | ||||||
UniProt | P62805 | ||||||
Other data | |||||||
Locus | Chr. 3 q13.13 | ||||||
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