Granulocyte-macrophage colony-stimulating factor
Mammalian protein found in Homo sapiens / From Wikipedia, the free encyclopedia
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Not to be confused with granulocyte colony-stimulating factor or macrophage colony-stimulating factor.
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
Quick Facts CSF2, Available structures ...
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Quick Facts Identifiers, Symbol ...
Granulocyte-macrophage colony-stimulating factor | |||||||||
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Symbol | GM_CSF | ||||||||
Pfam | PF01109 | ||||||||
Pfam clan | CL0053 | ||||||||
InterPro | IPR000773 | ||||||||
PROSITE | PDOC00584 | ||||||||
SCOP2 | 2gmf / SCOPe / SUPFAM | ||||||||
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Quick Facts Clinical data, ATC code ...
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ATC code | |
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CAS Number | |
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Chemical and physical data | |
Formula | C639H1006N168O196S8 |
Molar mass | 14434.54 g·mol−1 |
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Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils.[5]