Fosphenytoin
Anti-epileptic drug / From Wikipedia, the free encyclopedia
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Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is used in the acute treatment of convulsive status epilepticus.
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Trade names | Cerebyx, Pro-Epanutin |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604036 |
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Routes of administration | Intravenous, intramuscular |
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Bioavailability | 100% (IM) |
Protein binding | 95–99% |
Metabolism | Liver |
Elimination half-life | 15 minutes to convert to phenytoin |
Excretion | Kidney (as phenytoin) |
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Formula | C16H15N2O6P |
Molar mass | 362.278 g·mol−1 |
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Fosphenytoin was developed in 1996.[2] On 18 November 2004, Sicor (a subsidiary of Teva) received a tentative approval letter from the United States Food and Drug Administration for a generic version of fosphenytoin.[3]