Fischer indole synthesis
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The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions.[1][2] The reaction was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method.
Quick Facts Identifiers ...
Fischer indole synthesis | |
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Named after | Hermann Emil Fischer |
Reaction type | Ring forming reaction |
Identifiers | |
Organic Chemistry Portal | fischer-indole-synthesis |
RSC ontology ID | RXNO:0000064 |
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This reaction can be catalyzed by Brønsted acids such as HCl, H2SO4, polyphosphoric acid and p-toluenesulfonic acid or Lewis acids such as boron trifluoride, zinc chloride, and aluminium chloride.