File:Structure_of_Cdk2–cyclin_A–p27.pdf
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Summary
DescriptionStructure of Cdk2–cyclin A–p27.pdf |
English: The structure of the Cdk2–cyclin A–p27 complex, as determined by X-ray crystallography, reveals that the inhibitor p27 (red) stretches across the top of the cyclin–Cdk complex. Only the amino-terminal region of p27 is shown in the structure. The amino- terminal end of this fragment contains an RXL motif that interacts with the hydrophobic patch of cyclin A. The carboxy-terminal end of the p27 fragment interacts extensively with the beta sheet of Cdk2, causing extensive disruptions to its structure; p27 also inserts into the ATP-binding site of Cdk2 and directly inhibits ATP binding. (PDB 1jsu)[1] |
Date | |
Source | The Cell Cycle. Principles of Control. |
Author | David O Morgan |
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1 January 2007
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 02:12, 8 April 2020 | 1,425 × 1,237 (3.71 MB) | Rob Hurt | Uploaded a work by David O Morgan from The Cell Cycle. Principles of Control. with UploadWizard |
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Short title | Structure of Cdk2–cyclin A–p27.pdf |
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Software used | Serif Affinity Designer (Mar 31 2020) |
Conversion program | PDFlib+PDI 9.1.2p1-i (OS X/macOS) |
Encrypted | no |
Page size | 684 x 594 pts |
Version of PDF format | 1.7 |