Febuxostat
Chemical compound / From Wikipedia, the free encyclopedia
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Febuxostat, sold under the brand names Uloric among others, is a medication used long-term to treat gout due to high uric acid levels.[6] It is generally recommended only for people who cannot take allopurinol.[7][8] When initially started, medications such as NSAIDs are often recommended to prevent gout flares.[6][8] It is taken by mouth.[6]
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Trade names | Uloric, Adenuric, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a609020 |
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Routes of administration | By mouth |
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Bioavailability | ≥84% absorbed |
Protein binding | 99.2% to albumin |
Metabolism | via CYP1A1, 1A2, 2C8, 2C9, UGT1A1, 1A8, 1A9[5] |
Elimination half-life | ~5–8 hours |
Excretion | Urine (~49%, mostly as metabolites, 3% as unchanged drug); feces (~45%, mostly as metabolites, 12% as unchanged drug) |
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ECHA InfoCard | 100.207.329 |
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Formula | C16H16N2O3S |
Molar mass | 316.38 g·mol−1 |
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Common side effects include liver problems, nausea, joint pain, and a rash.[6] Serious side effects include an increased risk of death as compared with allopurinol, Stevens–Johnson syndrome, and anaphylaxis.[8][7] Use is not recommended during pregnancy or breastfeeding.[8] It inhibits xanthine oxidase, thus reducing production of uric acid in the body.[6]
Febuxostat was approved for medical use in the European Union in 2008, and in the United States in 2009.[9][6] A generic version was approved in 2019.[10][11]