Ergotamine
Chemical compound in the ergot family of alkaloids / From Wikipedia, the free encyclopedia
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Ergotamine, sold under the brand names Cafergot (with caffeine) and Ergomar among others, is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline.[5] It is structurally similar to several neurotransmitters, and it acts as a vasoconstrictor.
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Trade names | Cafergot (with caffeine), Ergomar, others |
Other names | 2'-Methyl-5'α-benzyl-12'-hydroxy-3',6',18-trioxoergotaman; 9,10α-Dihydro-12'-hydroxy-2'-methyl-5'α-(phenylmethyl)ergotaman-3',6',18-trione |
AHFS/Drugs.com | Monograph |
Routes of administration | Oral |
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Bioavailability | Intravenous: 100%,[2] Intramuscular: 47%,[3] Oral: <1%[4] (Enhanced by co-administration of caffeine[2]) |
Metabolism | Hepatic[3] |
Elimination half-life | 2 hours[3] |
Excretion | 90% biliary[3] |
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ECHA InfoCard | 100.003.658 |
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Formula | C33H35N5O5 |
Molar mass | 581.673 g·mol−1 |
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It is used for acute migraines, sometimes with caffeine. Medicinal use of ergot fungus began in the 16th century, for the induction of childbirth; but dosage uncertainty discouraged its use. It has been used to prevent post-partum hemorrhage (bleeding after childbirth). It was first isolated from the ergot fungus by Arthur Stoll, at Sandoz in 1918, and was marketed as Gynergen in 1921.[6]