Diffuse axonal injury
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Diffuse axonal injury (DAI) is a brain injury in which scattered lesions occur over a widespread area in white matter tracts as well as grey matter.[1][2][3][4][5][6][7] DAI is one of the most common and devastating types of traumatic brain injury[8] and is a major cause of unconsciousness and persistent vegetative state after severe head trauma.[9] It occurs in about half of all cases of severe head trauma and may be the primary damage that occurs in concussion. The outcome is frequently coma, with over 90% of patients with severe DAI never regaining consciousness.[9] Those who awaken from the coma often remain significantly impaired.[10]
Diffuse axonal injury | |
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Two MRI images of a patient with diffuse axonal injury resulting from trauma, at 1.5 tesla field strength. Left: conventional gradient recalled echo (GRE). Right: Susceptibility weighted image (SWI). | |
Specialty | Neurology |
DAI can occur across the spectrum of traumatic brain injury (TBI) severity, wherein the burden of injury increases from mild to severe.[11][12] Concussion may be a milder type of diffuse axonal injury.[12][13]