Diacylglycerol lipase
Enzyme that breaks down diacylglycerol in many organisms. / From Wikipedia, the free encyclopedia
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Diacylglycerol lipase, also known as DAG lipase, DAGL, or DGL, is an enzyme that catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol:[1]
diacylglycerol + H2O ⇌ monoacylglycerol + free fatty acid
diacylglycerol lipase α | |||||||
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Identifiers | |||||||
Symbol | DAGLA | ||||||
Alt. symbols | C11orf11 | ||||||
NCBI gene | 747 | ||||||
HGNC | 1165 | ||||||
RefSeq | NM_006133 | ||||||
UniProt | Q9Y4D2 | ||||||
Other data | |||||||
EC number | 3.1.1.116 | ||||||
Locus | Chr. 11 q12.3 | ||||||
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diacylglycerol lipase β | |||||||
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Identifiers | |||||||
Symbol | DAGLB | ||||||
NCBI gene | 221955 | ||||||
HGNC | 28923 | ||||||
RefSeq | NM_139179 | ||||||
UniProt | Q8NCG7 | ||||||
Other data | |||||||
EC number | 3.1.1.116 | ||||||
Locus | Chr. 7 p22.1 | ||||||
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DAGL has been studied in multiple domains of life, including bacteria, fungi, plants, insects, and mammals.[4] By searching with BLAST for the previously sequenced microorganism DAGL,[5] Bisogno et al discovered two distinct mammalian isoforms, designated DAGLα (DAGLA) and DAGLβ (DAGLB).[1] Most animal DAGL enzymes cluster into the DAGLα and DAGLβ isoforms.[4]
Mammalian DAGL is a crucial enzyme in the biosynthesis of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid in tissues.[1] The endocannabinoid system has been identified to have considerable involvement in the regulation of homeostasis and disease.[6] As a result, much effort has been made toward investigating the mechanisms of action and the therapeutic potential of the system's receptors, endogenous ligands, and enzymes like DAGLα and DAGLβ.[6]