Ceftaroline fosamil
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Ceftaroline fosamil (INN) /sɛfˈtæroʊliːn/, brand name Teflaro in the US and Zinforo in Europe,[1][2] is a cephalosporin antibiotic with anti-MRSA activity.[3] Ceftaroline fosamil is a prodrug of ceftaroline. It is active against methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive bacteria. It retains some activity of later-generation cephalosporins having broad-spectrum activity against Gram-negative bacteria, but its effectiveness is relatively much weaker.[4][5] It is currently being investigated for community-acquired pneumonia[6] and complicated skin and skin structure infection.[7][8][9]
This article needs more reliable medical references for verification or relies too heavily on primary sources. (September 2019) |
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Trade names | Teflaro, Zinforo |
Other names | PPI 0903, TAK-599 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a611014 |
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Routes of administration | Intravenous |
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Protein binding | 20% |
Elimination half-life | 2.5 hours |
Excretion | Urine (88%), faeces (6%) |
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Formula | C22H21N8O8PS4 |
Molar mass | 684.67 g·mol−1 |
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Ceftaroline is being developed[when?] by Forest Laboratories, under a license from Takeda.[9] Ceftaroline received approval from the U.S. Food and Drug Administration (FDA) for the treatment of community-acquired bacterial pneumonia and acute bacterial skin infections on 29 October 2010.[10] In vitro studies show it has a similar spectrum to ceftobiprole,[not verified in body] the only other fifth-generation cephalosporin to date,[when?] although no head-to-head clinical trials have been conducted. Ceftaroline and ceftobiprole are on an unnamed subclass of cephalosporins by the Clinical and Laboratory Standards Institute (CLSI).[not verified in body]
It was removed from the World Health Organization's List of Essential Medicines in 2019.[11]