Cabergoline
Chemical compound / From Wikipedia, the free encyclopedia
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Cabergoline, sold under the brand name Dostinex among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson's disease, and for other indications.[1] It is taken by mouth.
This article needs more reliable medical references for verification or relies too heavily on primary sources. (August 2023) |
Quick Facts Clinical data, Trade names ...
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Trade names | Dostinex, others |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth |
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Bioavailability | First-pass effect seen; absolute bioavailability unknown |
Protein binding | Moderately bound (40–42%); concentration-independent |
Metabolism | Liver, predominately via hydrolysis of the acylurea bond or the urea moiety |
Elimination half-life | 63–69 hours (estimated) |
Excretion | Urine (22%), feces (60%) |
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ECHA InfoCard | 100.155.380 |
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Formula | C26H37N5O2 |
Molar mass | 451.615 g·mol−1 |
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Cabergoline is an ergot derivative and a potent dopamine D2 receptor agonist.[2]
Cabergoline was patented in 1980 and approved for medical use in 1993.[3] It is on the World Health Organization's List of Essential Medicines.[4]