Bruce Beutler
American immunologist and geneticist / From Wikipedia, the free encyclopedia
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Bruce Alan Beutler (/ˈbɔɪtlər/ BOYT-lər; born December 29, 1957) is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "discoveries concerning the activation of innate immunity."[1] Beutler discovered the long-elusive receptor for lipopolysaccharide (LPS; also known as endotoxin). He did so by identifying spontaneous mutations in the gene coding for mouse Toll-like receptor 4 (Tlr4) in two unrelated strains of LPS-refractory mice and proving they were responsible for that phenotype.[2] Subsequently, and chiefly through the work of Shizuo Akira, other TLRs were shown to detect signature molecules of most infectious microbes, in each case triggering an innate immune response.[3][4][5][6][7]
Bruce Beutler | |
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Born | (1957-12-29) December 29, 1957 (age 66) |
Nationality | American |
Alma mater | University of Chicago, University of California, San Diego |
Spouse(s) | Barbara Lanzl (c. 1980-1988; divorced; 3 children) |
Awards | 2011 Nobel Prize in Physiology or Medicine |
Scientific career | |
Fields | Immunology |
Institutions | University of Texas Southwestern Medical Center |
The other half of the Nobel Prize went to Ralph M. Steinman for "his discovery of the dendritic cell and its role in adaptive immunity."[1]
Beutler is currently a Regental Professor and Director of the Center for the Genetics of Host Defense at the University of Texas Southwestern Medical Center in Dallas, Texas.[8][9]