AIM2
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Interferon-inducible protein AIM2 also known as absent in melanoma 2 or simply AIM2 is a protein that in humans is encoded by the AIM2 gene.[5][6]
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AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin.[7] AIM2-like receptor (ALR) family was founded on AIM2 and now consists of four members in human genome.[8] Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), resulting in caspase-1 binding, and forming of AIM2 inflammasome. This signaling contributes to the defense against bacterial and viral DNA.