ACVR1B
Protein-coding gene in humans / From Wikipedia, the free encyclopedia
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Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene.[5][6]
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ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.[7] ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto.[8]