GroEL je protein koji pripada porodici molekulskih šaperona pratioca, a nalazi se u velikom broju bakterija Potreban je za efikasno savijanje mnogih proteina. Da bi učinkovito funkcionirao, GroEL zahtijeva kompleks poklopca GroES, povezan s proteinima. Kod eukariota to su proteini Hsp60 i Hsp10, strukturno i funkcionalno gotovo identični GroEL-u odnosno GroES-u.[5] Slična struktura proteina postoji u hloroplastima određenih biljaka. Ovo prisustvo proteina pruža dokaze o evolucijskoj vezi razvoja mitohondrija i hloroplasta preko endosimbioze.[6]
Kratke činjenice Dostupne strukture, PDB ...
GroEL |
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Identifikatori |
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Aliasi | HSPD1 |
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Vanjski ID-jevi | OMIM: 118190 MGI: 96242 HomoloGene: 1626 GeneCards: HSPD1 |
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Ontologija gena |
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Molekularna funkcija | • nucleotide binding • chaperone binding • p53 binding • single-stranded DNA binding • ATPase activity • GO:0001948, GO:0016582 vezivanje za proteine • double-stranded RNA binding • DNA replication origin binding • ATP binding • ubiquitin protein ligase binding • protein folding chaperone activity • unfolded protein binding • vezivanje sa RNK • hydrolase activity • high-density lipoprotein particle binding • vezivanje enzima • apolipoprotein binding • apolipoprotein A-I binding • lipopolysaccharide binding • isomerase activity
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Ćelijska komponenta | • citoplazma • cyclin-dependent protein kinase activating kinase holoenzyme complex • lipopolysaccharide receptor complex • early endosome • mitohondrija • clathrin-coated pit • coated vesicle • Egzosom • GO:0005578 Vanćelijski matriks • mitochondrial matrix • Vanćelijsko • mitochondrial inner membrane • citosol • ćelijska membrana • cell surface • membrana • secretory granule • GO:0009327 makromolekulani kompleks
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Biološki proces | • chaperone-mediated protein complex assembly • positive regulation of interleukin-12 production • positive regulation of interleukin-10 production • protein stabilization • protein maturation • positive regulation of macrophage activation • MyD88-dependent toll-like receptor signaling pathway • isotype switching to IgG isotypes • B cell activation • B cell cytokine production • response to unfolded protein • B cell proliferation • Savijanje proteina • positive regulation of T cell mediated immune response to tumor cell • protein refolding • positive regulation of interleukin-6 production • positive regulation of apoptotic process • response to cold • GO:0022415 viral process • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • 'de novo' protein folding • protein import into mitochondrial intermembrane space • chaperone-mediated protein folding • apoptotic mitochondrial changes • positive regulation of interferon-alpha production • positive regulation of interferon-gamma production • T cell activation • negative regulation of apoptotic process • positive regulation of T cell activation • mitochondrion organization
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 2: 197.49 – 197.52 Mb | Chr 1: 55.12 – 55.13 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori