User:Nsterge2/Mitotic catastrophe
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Mitotic Catastrophe has been defined as either an cellular mechanism to prevent cancerous cell proliferation that results in the cell no longer dividing or cell death in cells that undergo a defective mitosis or as a mode of cellular death that occurs following improper cell cycle progression or entrance[1][2]. Mitotic catastrophe can be induced by prolonged activation of the spindle assembly checkpoint, errors in mitosis, or DNA damage and functioned to prevent genomic instability[3]. It is a mechanism that is being researched as a potential therapeutic target in cancers, and numerous approved therapeutics induce mitotic catastrophe[4].
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