Mesna
Chemical compound / From Wikipedia, the free encyclopedia
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Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder.[1] It is used either by mouth or injection into a vein.[1]
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Pronunciation | /ˈmɛznə/ |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth, intravenous |
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Bioavailability | 45–79% (by mouth) |
Metabolism | Oxidised in circulation |
Elimination half-life | 0.36–8.3 hours |
Excretion | kidney |
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ECHA InfoCard | 100.039.336 |
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Formula | C2H5NaO3S2 |
Molar mass | 164.17 g·mol−1 |
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Common side effects include headache, vomiting, sleepiness, loss of appetite, cough, rash, and joint pain.[1] Serious side effects include allergic reactions.[1] Use during pregnancy appears to be safe for the baby but this use has not been well studied.[2] Mesna is an organosulfur compound.[3] It works by altering the breakdown products of cyclophosphamide and ifosfamide found in the urine making them less toxic.[1]
Mesna was approved for medical use in the United States in 1988.[1] It is on the World Health Organization's List of Essential Medicines.[4]