Succinic semialdehyde
Chemical compound / From Wikipedia, the free encyclopedia
Succinic semialdehyde (SSA) is a GABA metabolite. It is formed from GABA by the action of GABA transaminase (4-aminobutyrate aminotransferase) and further oxidised to become succinic acid, which enters TCA cycle. SSA is oxidized into succinic acid by the enzyme succinic semialdehyde dehydrogenase, which uses NAD+ as a cofactor.[2] [3] When the oxidation of succinic semialdehyde to succinic acid is impaired, accumulation of succinic semialdehyde takes place which leads to succinic semialdehyde dehydrogenase deficiency.[3]
Quick Facts Names, Identifiers ...
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Preferred IUPAC name
4-Oxobutanoic acid | |
Identifiers | |
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3D model (JSmol) |
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ChEBI | |
ChemSpider |
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ECHA InfoCard | 100.155.728 |
KEGG |
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MeSH | Succinic+semialdehyde |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C4H6O3 | |
Molar mass | 102.089 g/mol |
Appearance | oil |
Boiling point | 135 °C (275 °F; 408 K) at 14 mmHg |
soluble in water, ethanol, benzene, diethyl ether[1] | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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