Benzathine benzylpenicillin
Antibiotic / From Wikipedia, the free encyclopedia
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Benzathine benzylpenicillin, also known as benzathine penicillin G (BPG), is an antibiotic medication useful for the treatment of a number of bacterial infections.[3] Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws.[3][5] It is also used to prevent rheumatic fever.[5] It is given by injection into a muscle.[3][5] It is known as "Peanut Butter Shot" in US military slang due to its appearance.[6]
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Benzylpenicillin | antibiotic |
Benzathine | stabilizer |
Clinical data | |
Trade names | Bicillin L-A,[1] Permapen, others |
Other names | penicillin benzathine benzyl, benzathine penicillin, penicillin G benzathine, benzylpenicillin benzathine[2] |
AHFS/Drugs.com | Professional Drug Facts |
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Routes of administration | Intramuscular injection[3] |
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E number | E708 (antibiotics) |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.014.782 |
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Side effects include allergic reactions including anaphylaxis, and pain at the site of injection.[5] When used to treat syphilis a reaction known as Jarisch-Herxheimer may occur.[5] It is not recommended in those with a history of penicillin allergy or those with syphilis involving the nervous system.[5][3] Use during pregnancy is generally safe.[3] It is in the penicillin and beta lactam class of medications and works via benzylpenicillin.[3][5] The benzathine component slowly releases the penicillin making the combination long acting.[7]
Benzathine benzylpenicillin was patented in 1950.[2][8] It is on the World Health Organization's List of Essential Medicines.[9]