Naltrexone/bupropion
Medication for treatment of obesity / From Wikipedia, the free encyclopedia
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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity.[4][6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant.[4] It is taken by mouth.[4] Both medications have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight.[7]
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Naltrexone | Opioid receptor antagonist |
Bupropion | Norepinephrine-dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist |
Clinical data | |
Trade names | Contrave, Mysimba |
AHFS/Drugs.com | Monograph |
Routes of administration | By mouth |
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In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name Contrave.[8][9] The combination was subsequently approved in the European Union in the spring of 2015, where it is sold under the name Mysimba.[5][10] It was approved in Canada under the Contrave brand name in 2018.[11]