Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be referred to as Gq alpha, Gαq, or Gqα.
Gq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-β) enzymes. PLC-β in turn hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium into the cytoplasm, while DAG acts as a second messenger that activates protein kinase C (PKC).
Quick Facts guanine nucleotide binding protein (G protein), q polypeptide, Identifiers ...
Close
Quick Facts guanine nucleotide binding protein (G protein), alpha 11 (Gq class), Identifiers ...
Close
Quick Facts guanine nucleotide binding protein (G protein), alpha 14, Identifiers ...
Close
Quick Facts guanine nucleotide binding protein (G protein), alpha 15 (Gq class), Identifiers ...
Close