Growth hormone secretagogue receptor
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone".[5][6] The role of GHS-R is thought to be in regulating energy homeostasis and body weight.[7] In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra.[8] Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even in the heart.[9]