Chemical ligation
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This article is about ligation of peptides. For ligation of nucleic acids, see Ligation (molecular biology). For other uses, see Ligation (disambiguation).
Chemical ligation is the chemoselective condensation of unprotected peptide segments enabled by the formation of a non-native bond at the ligation site.
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Chemical ligation is usually carried out in aqueous solution. Multiple consecutive chemical ligation reactions can be used to make proteins of the typical size found in Nature, i.e. with polypeptide chains containing 200-300 amino acids, produced by total synthesis.